Ulingo lwezonyango luvuliwe ePoland oluza kuvavanya ukuba i-regorafenib ingasetyenziselwa ukunyanga umhlaza wamathambo. I-Regorafenib luhlobo lwechiza elibizwa ngokuba yi-tyrosine kinase inhibitor (TKI). I-TKIs isebenza ngokuthintela ukusebenza kwee-enzyme ezibizwa ngokuba yi-tyrosine kinases. Babandakanyeka kwiinkqubo ezininzi emzimbeni. Oku kuquka ukukhula komhlaza. Abaphandi banethemba lokuba ukuvimba ezi enzymes kunokunceda ukunyanga i-osteosarcoma (OS). Ii-TKIs zamkelwe ukuba zinyange ezinye ii-cancer.
Ulingo luza kujonga kwakhona indlela imfuzo yomhlaza eyichaphazela ngayo indlela umntu aza kusabela ngayo kunyango. Izigulane kolu lingo ziya kuba uvavanyo lwemolekyuli ukubona ukuba zeziphi na iinguqu zemfuza abanazo.
Sivuyile udliwano-ndlebe noNjingalwazi Anna Raciborska malunga neREGBONE. Unjingalwazi uRaciborsk yiNtloko yeSebe le-Oncology kunye ne-Oncology yoCando lwaBantwana kunye noLutsha eWarsaw, ePoland.
Nceda ungasixelela ngolingo lweREGBONE?
Iprojekthi ye-REGBONE lulingo lwezonyango olungarhwebi (aluxhaswa ngemali yinkampani yoxubo-mayeza). Injongo yale projekthi kukuphucula iziphumo zonyango kwizigulane ezineengcambu zethambo ezinobungozi eziphambili, ezingaphenduliyo kunyango oluqhelekileyo, ngokunyusa ukufumaneka kwonyango oluphezulu.
Ulingo luya kuphuhlisa iindlela zonyango zisebenzisa i-molecular diagnostics ephezulu kwizigulane ezingakhange ziphendule kwi-regimen yonyango eqhelekileyo.
Iinjongo zeprojekthi yeREGBONE zezi:
(1) ukuqikelela ubume kunye namaxesha otshintsho kwizicubu zethumba.
(2) ukuthelekisa uvavanyo lwemolekyuli iziphumo ngedatha yeklinikhi. Oku kuya kuvumela uvavanyo lokuqala lwempembelelo yesimo sokuguquka kwimeko yeklinikhi, inkqubo yonyango kunye ne-prognosis.
(3) ukubandakanya unyango olutsha ekujoliswe kulo regorafenib kunyango olusemgangathweni.
Njengenxalenye yolingo lwe-REGBONE i-immortalized cell line (iiseli zomhlaza ezikhuliswe elabhoratri) ziya kuthathwa ukuze kufundwe uphuhliso lwesi sifo, uvakalelo lwamachiza, kunye neendlela zokuxhathisa kumachiza.
Le projekthi ixhaswa ngemali ngokupheleleyo yi-Arhente yoPhando lwezoNyango lwasePoland (ABM) kwiimali zebhajethi karhulumente.
Loluphi uphando olukhokelele kolu lingo?
Iithumba zamathambo eziphambili zizifo ezinqabileyo kakhulu. Phantse i-1,100 - i-1,200 amatyala amatsha amathumba anobungozi afunyaniswa kubantwana ngonyaka ngamnye ePoland. Amathumba amathambo amalunga ne-6-7% yamatyala. (Oku ziimeko ezi-6-7 kuzo zonke iimeko ezili-100 zomhlaza wabantwana).
Ngelishwa, ngaphandle koxinzelelo lonyango kwizigulane ezinomhlaza wamathambo, iziphumo azizange ziphuculwe ngaphezu kweminyaka engama-30. Ngesi sizathu, ezinye iindlela zonyango ziyaphandwa kulo lonke ihlabathi.
Ngokusekwe kuphando lwangoku, ukufakwa kwee-TKIs kubonakala ngathi kuyathembisa. Kwakhona, izifundo zethu zokuqala zibonise ireyithi yokuphendula ebalulekileyo kule klasi yamachiza kwi-primary refractory bone sarcomas (umhlaza wethambo ongaphenduliyo kunyango oluqhelekileyo).
Kutheni uvavanyo lwemolekyuli lubalulekile?
Ukuchongwa kotshintsho olutsha kwiithumba zethambo kuye kwakhokelela ekuqondeni okungcono kwisiseko se-molecular of tumors. Oku kuphucule indima yophando lwemfuzo kwimisebenzi yemihla ngemihla. Nangona Imbali yembali iimviwo okwangoku zisisiseko sokuxilongwa kwamathumba ethambo, iindlela ezintsha zebhayoloji yemolekyuli zivumela ukucocwa kokuxilongwa kwiimeko ezininzi. Kwixesha elizayo elingekude, ziya kuba sisiseko sokwahlulwa kwezi zomhlaza. Ezi ndlela zikwajongwe ukutshatisa izigulane kunyango olujoliswe kwimolekyuli.
Ngubani onokuthatha inxaxheba kolu lingo lwezonyango?
Umda wale projekthi kukugubungela bonke abantu babantwana, abafikisayo, kunye nabantu abadala abancinci ukusuka kwiminyaka emi-2 ukuya kwiminyaka engama-21. sarcoma okanye OS.
Le projekthi iqhutywa kwiZiko loMama kunye noMntwana (IMID) kunye neZiko loPhando leSizwe le-Oncology (PIB-NIO) njengomdibanisi. Kwakhona, i Umbutho weSAROMA woNcedo lweZigulana ezineSarcomas kunye neMelanomas (njengombutho wesigulane) ungumdibanisi weprojekthi.
Ngawaphi amanyathelo alandelayo lwakube lugqityiwe ulingo?
Siyathemba ukuba iziphumo zophando ziya kuvumela i-regorafenib ukuba ifakwe njengonyango oluqhelekileyo kunyango lwe-primary bone tumors, kwaye olu nyango luya kubuyiselwa kuzo zonke izigulane ezinesidingo (iindleko zeyeza ziya kuhlawulwa ngurhulumente). Ukuba akunjalo, okanye ukuba kuyimfuneko, siya kuqhubeka sikhangela izisombululo zokuphucula ukusinda kweli qela lezigulane.
Leliphi icebiso onokuthi ulinike nabani na ocinga ukuthatha inxaxheba kulingo lwezonyango?
Ukuthatha inxaxheba kulingo lwezonyango kunika izigulana ithuba lokusebenzisa unyango lwamva nje, iyeza elitsha, okanye inkqubo yonyango. Nangona kungekho siqinisekiso sokuphumelela, ngokuqinisekileyo abaguli bafanele bavakalelwe kukuba banikwa olona nyango lufanelekileyo. Oku kubaluleke ngakumbi ukuba umntwana unomhlaza. Kwimeko yomhlaza apho unyango olusemgangathweni luye lwasilela, ukufakwa kulingo lwezonyango kunokuba lithuba lokufumana iyeza elisebenzayo. Izigulane ezibandakanyiweyo kwiimvavanyo zeklinikhi azifaki iindleko ezinxulumene nonyango, ziphantsi kokunyamekela ngokupheleleyo kweqela loogqirha kunye nabongikazi, kwaye banokufikelela kwiinkqubo zonyango kunye nokuxilongwa kwinqanaba eliphezulu. Kufuneka kukhunjulwe ukuba izilingo zeklinikhi zisisiseko senkqubela phambili yenjongo kwiyeza.
Ke ngoko masingoyiki amalingo ekliniki. Banika ithuba lekamva elingcono.
Ungafumana ngakumbi malunga nolingo kwi website yovavanyo. Isishwankathelo solingo sinokufunyanwa kwakhona ONTEX.
Siyaqonda ukuba ulingo lwezonyango lunokubhida. Ndwendwela wethu isixhobo sovavanyo lwezonyango iimpendulo zemibuzo malunga nolingo lwezonyango kunye neengcebiso zokulungiselela ukuqeshwa.
Ukuba unomdla wokuthatha inxaxheba kulingo lwezonyango kusoloko kubalulekile ukuxoxa ngolingo noogqirha bakho kuqala. Baza kulazi ityala lakho ngcono kwaye babenakho ukukucebisa malunga nokuba ityala linokufaneleka.
Sithanda ukubulela uNjingalwazi Raciborska ngokuthatha inxaxheba kudliwano-ndlebe. Sikwathanda ukubulela umququzeleli wesifundo uKatarzyna Maleszewska ngokusinceda ukuba siyilungiselele.
Nceda uqaphele ukuba okubhaliweyo kwizibiyeli kongezwe liQela le-Osteaosarcoma ngoku.