

Osteosarcoma Toolkit
Welcome to our Osteosarcoma Toolkit. Here you will find information on what osteosarcoma is and how it is diagnosed and treated.
Read our whole toolkit or click on the links below to jump to specific sections.
What are the Symptoms of Osteosarcoma?
How is Osteosarcoma Diagnosed?
What does the Cancer Grade and Stage Mean?
Living With and Beyond Osteosarcoma.
Other Resources about Osteosarcoma.
What is Cancer?
The body is made up of trillions of cells that contain DNAThe molecule that contains the genetic information that makes you the person you are. More, the body’s genetic code. This code is like a recipe that determines how we grow and develop and ultimately make us us. Cells are constantly dividing and during this process the genetic code is copied. Sometimes mistakes happen and the code is copied incorrectly. These changes in genetic code are known as mutations and most of the time they are harmless (the recipe still works). However in some cases mutations result in cells that divide uncontrollably leading to cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More.
CancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More cells will often start in one place and form a mass known as a tumourA mass of cells that are growing where they shouldn’t be. Tumours can be benign or malignant. Benign tumours do not spread to other parts of the body whereas malignant tumours are cancerous and have the potential to spread. More. These cells can spread to other areas of the body in a process known as metastasisCancer cells have spread from the site where they developed to other parts of the body. More. It is important to note that some tumors are benign (not cancerous) and do not spread to other areas.
There are many different types of cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More and diagnosing which cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More you have is the first step to developing a treatment plan.
What is Osteosarcoma?
Osteosarcoma is a type of cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More that arises in the bone and affects 3.4 people per million every year worldwide. It most frequently arises at the ends of long bones (e.g. leg and arm bones), in an area known as the metaphysis. Bone growth is regulated by cells called osteoclasts and osteoblasts, which work together to keep bones healthy. Osteoclasts remove old bone, while osteoblasts make new bone. In osteosarcoma, the cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More cells cause the signals between these cells to be disrupted resulting in the osteoclasts destroying healthy bone and leading to tumourA mass of cells that are growing where they shouldn’t be. Tumours can be benign or malignant. Benign tumours do not spread to other parts of the body whereas malignant tumours are cancerous and have the potential to spread. More growth.

What Causes Osteosarcoma?
The cause of osteosarcoma is unknown. No environmental factors or specific mutation have been identified as a causative factor. However, there are certain factors that may increase an individual’s risk of developing osteosarcoma. In other words having these risk factors doesn’t mean you will develop osteosarcoma but that you are at greater risk than someone who doesn’t have these factors.
Risk Factors
- Genetic Conditions (Li Fraumeni syndrome and Retinoblastoma)
- Age (Adolescents and young adults – may be associated with bone growth)
- Paget’s disease (A condition that causes abnormal bone formation)
- Previous Radiotherapy (Radiotherapy is used to treat cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More but involves high doses of radiation, which can increase your risk of developing cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More in the future)
What are the symptoms of Osteosarcoma?
The most common symptom of osteosarcoma are:
- Progressive bone pain that is usually worse at night and disrupts sleep.
- Swelling which can restrict movement.
- Breaks from minor injuries.
There are also non specific symptoms that are seen across all cancers which include loss of appetite and weight loss.
How is Osteosarcoma Diagnosed?
Here we provide an overview of If a doctor suspects osteosarcoma, they will organise a number of scans to look at the bone(s) in more detail. This will normally include an x-ray followed by an MRI or CT scan (see our ‘Types of Scan’ page to find out more). Next, a biopsyA medical procedure that involves removing a small amount of tissue from the body which is then examined under a microscope. More will be taken. This involves using a needle to remove some cells from the bone. A doctor known as a pathologist will examine the cells under a microscope and confirm if the cells are cancerous and what type of cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More it is. If osteosarcoma is confirmed, a full body scan known as a staging scan (or PET scan) will be performed to see if the cancerous cells have spread to other areas in the body. The case will then usually be referred to a team of specialist sarcoma doctors who will meet to formulate a personalised treatment plan. The meeting is known as a Multidisciplinary TeamA group of medical professionals who meet to plan a person's treatment. More Meeting (MDT).
Each person’s diagnostic pathway will be slightly different. We have provided an overview of what to expect but a diagnosis may be made at any point during the investigations.
01 | X-Ray
A scan is performed to look at the bone in more detail.
02 | MRI/CT
This is followed by scans that build more detailed images of the bone and surrounding structures.
03 | BiopsyA medical procedure that involves removing a small amount of tissue from the body which is then examined under a microscope. More
A small sample of cells is then removed from bone and examined under a microscope.
04 | PET Scan
A scan to see if the cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More cells are elsewhere in the body will be performed. This will be used to stageA way to characterize the size and spread of cancer and help to guide treatment. More the cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More.
05 | MDT
Experts come together to discuss your case and create a treatment plan.
What does the Cancer Grade and Stage Mean?
You may hear doctors refer to your cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More as a certain gradeHow quickly cancer cells are growing and dividing. More or stageA way to characterize the size and spread of cancer and help to guide treatment. More. The stageA way to characterize the size and spread of cancer and help to guide treatment. More and gradeHow quickly cancer cells are growing and dividing. More of your cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More helps doctors to formulate a treatment plan.
The gradeHow quickly cancer cells are growing and dividing. More of a cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More refers to how it looks under the microscope.
- Low GradeHow quickly cancer cells are growing and dividing. More Cancers – The cells look relatively normal and usually divide slowly. These cancers are slow growing and less likely to spread.
- High GradeHow quickly cancer cells are growing and dividing. More CancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More – The cells look abnormal and usually divide quickly. These cancers are normally fast growing and may spread to other areas in the body.
The stageA way to characterize the size and spread of cancer and help to guide treatment. More of your cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More refers to its size and whether it has spread to other areas of the body. It is used by doctors to create treatment plans. There are several different staging systems used for osteosarcoma with the most common being TNM (tumourA mass of cells that are growing where they shouldn’t be. Tumours can be benign or malignant. Benign tumours do not spread to other parts of the body whereas malignant tumours are cancerous and have the potential to spread. More, node, metastasisCancer cells have spread from the site where they developed to other parts of the body. More) and Enneking staging system.
TNM Staging
TNM stands for tumourA mass of cells that are growing where they shouldn’t be. Tumours can be benign or malignant. Benign tumours do not spread to other parts of the body whereas malignant tumours are cancerous and have the potential to spread. More, node, metastasisCancer cells have spread from the site where they developed to other parts of the body. More.
TumourA mass of cells that are growing where they shouldn’t be. Tumours can be benign or malignant. Benign tumours do not spread to other parts of the body whereas malignant tumours are cancerous and have the potential to spread. More refers to how big the mass is.
- T1 – The tumourA mass of cells that are growing where they shouldn’t be. Tumours can be benign or malignant. Benign tumours do not spread to other parts of the body whereas malignant tumours are cancerous and have the potential to spread. More is less than 8cm wide.
- T2 – The tumourA mass of cells that are growing where they shouldn’t be. Tumours can be benign or malignant. Benign tumours do not spread to other parts of the body whereas malignant tumours are cancerous and have the potential to spread. More is more than 8cm wide.
- T3 – There is more than one area of cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More in the same bone.
Nodes describe if the cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More has spread to lymph nodes.
- N0 – No lymph nodes involved.
- N1 – Lymph nodes are involved.
M describes if the cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More has spread to other areas of the body.
- M0 – The cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More has not spread to other parts of the body.
- M1a – The cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More has spread to the lungs.
- M1b – The cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More has spread to other parts of the body (excluding the lung).
Once the cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More has been assigned a TMN stageA way to characterize the size and spread of cancer and help to guide treatment. More is then combined with the cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More gradeHow quickly cancer cells are growing and dividing. More to determine the stageA way to characterize the size and spread of cancer and help to guide treatment. More of the cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More (between 1 and 4). The table below demonstrates how they are combined. This does not include osteosarcoma that originates in the spine or pelvis. Find out more about the staging for these types of osteosarcoma at The American Society of Oncology.
StageA way to characterize the size and spread of cancer and help to guide treatment. More |
GradeHow quickly cancer cells are growing and dividing. More |
Size (T) |
Node (N) |
Spread (M) |
1A | Low | T1 | N0 | M0 |
1B | Low | T2/T3 | N0 | M0 |
2A | High | T1 | N0 | M0 |
2B | High | T2 | N0 | M0 |
3 | High | T3 | N0 | M0 |
4A | High or Low | T1/T2/T3 | N0 | M1a |
4B | High or Low | T1/T2/T3 | N1 | M1b |
How is Osteosarcoma Treated?
Although treatment varies slightly in different countries, most people will be offered chemotherapy and/or surgery depending on the stageA way to characterize the size and spread of cancer and help to guide treatment. More and gradeHow quickly cancer cells are growing and dividing. More of the cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More. Chemotherapy is a group of drugs that work by killing cells that are rapidly dividing. It has a systemicAffecting the whole body. More effect and may be given before and/or after surgery.
Surgery is performed to remove the primary tumourA mass of cells that are growing where they shouldn’t be. Tumours can be benign or malignant. Benign tumours do not spread to other parts of the body whereas malignant tumours are cancerous and have the potential to spread. More (the origin of the cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More cells). Surgeons are trained to preserve as much of the limb as possible but there are cases where amputationThe removal of a limb or extremity part with surgery. More is required. The Bone Cancer Research Trust has resources dedicated to providing support and information about amputations. In some cases, people will also have an operation known as a metastasectomy to remove any tumours that have formed in the lungs (the most common site of metastasisCancer cells have spread from the site where they developed to other parts of the body. More in osteosarcoma) .
Not everyone will respond to chemotherapy and alternative treatment options are limited. Fortunately, there are a number of drugs being tested in clinical trials. Clinical trials are medical research studies requiring patient participation to test a new treatment. You can find out more about clinical trials here.
Living With and Beyond Osteosarcoma?
Everyone’s cancerA disease where cells divide and grow uncontrollably and can spread to other areas of the body. More journey is different, and many people benefit from support during and after treatment. Throughout and after your treatment journey your consultant will book regular appointments to monitor your progress and address any concerns. You will usually be monitored for at least 10 years after finishing treatment although the frequency of visits will decrease.
There are also a number of wonderful organisations that provide mental and physical support for those living with and beyond osteosarcoma including loved ones. You can find a list of global organisations here.
Other Resources About Osteosarcoma
The Bone Cancer Research Trust have fact sheets and booklets about osteosarcoma for both adults and teenagers.
Sarcoma UK has information about osteosarcoma.
MIB agents have a book written by osteosarcoma families to support families through the treatment journey. The book is available in multiple different languages.
The NHS provides information about osteosarcoma.
“It’s that connection between the patient and the team and myself and also the interplay between looking after a teenager and their parents and the rest of the family I found really rewarding”
Dr Sandra Strauss, UCL
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