Tsebisa, Matlafatsa, Hokela

Osteosarcoma ke mofuta o mabifi oa mofetše oa masapo o tsoelang pele kapele. Kalafo ea osteosarcoma e lutse e ts'oana ka lilemo tse ka bang 40. Mekhoa e mecha ea phekolo e hloka ho etsoa lipatlisiso le ho lekoa ho ntlafatsa liphello tsa bakuli.

Mokhoa o mong oa kalafo o kenyelletsa ho kopanya meriana e lebisang bofokoling ba lisele tsa mofetše. Sena se bapisoa le chemotherapy e tloaelehileng e kanna ea se sebetse ka bo eona. Lebaka ke hobane liphekolo tse ling li ka lebisa lisele tsa mofetše (tse kotsi) ho feta chemotherapy e tloaelehileng. Sehlopha se seng sa meriana se shebana le likarolo tsa lisele tsa mofetše tse laolang hore na lisele tsa mofetše li hola le ho arohana kapele hakae. Sehlopha sena sa meriana se bitsoa tyrosine kinase lithibela (TKIs) 'me li sebetsa ka ho phekola likarolo tsa lisele tse bitsoang tyrosine kinase receptors (TKRs).

Pampiri ena e sheba hore na liphekolo tsena tsa TKI li sebetsa hantle hakae ho alafong osteosarcoma le hore na liphekolo tsena li ka sebelisoa ka mokhoa o sireletsehileng. Kalafo e ne e kenyelletsa phekolo ea TKI ka boeona le ho sebelisoa ka nako e le 'ngoe le chemotherapy e tloaelehileng.

Bafuputsi ba etsa see joang?

Bangoli ba pampiri ena ba ile ba sheba tšebeliso ea TKIs bakeng sa phekolo ea osteosarcoma ka ho hlahloba hore na lipatlisiso tse teng li hatisitsoe. Mokhoa ona o bitsoa tlhahlobo e hlophisitsoeng.

Tlhahlobo ea Tsamaiso ke Eng?

Tlhahlobo e hlophisitsoeng e kenyelletsa ho etsa patlisiso lilaeboraring tsa bongaka tsa inthaneteng bakeng sa lithuto tsa lipatlisiso tse amanang le sehlooho seo u se khethileng. Thutong ena, lihlooho tse khethiloeng li kenyelletsa kalafo ea osteosarcoma le TKI. Joale bafuputsi ba fokotsa lithuto tse nepahetseng ka ho fetisisa potsong ea bona ea lipatlisiso le ho bapisa mekhoa ea lipatlisiso e sebelisoang, hammoho le liphello tsa lithuto tsena tse khethiloeng. Tlhahlobisong ena e hlophisitsoeng, lipampiri life kapa life tse phatlalalitsoeng pele ho 2020 li ne li qheletsoe ka thoko, kaha ho bohlokoa ho sebelisa tlhaiso-leseling ea morao-rao. Ka kakaretso, lithuto tsa 93 tsa liteko tsa bongaka tse amanang le phekolo ea TKI li kenyelelitsoe tlhahlobisong ena.

Chate e phallang e nang le methati e latelang: 1. Etsa qeto ka sehlooho sa lipatlisiso le mantsoe a ho batla ao u ka a sebelisang (mohlala, osteosarcoma) ho fumana liphetho tse ntle ka ho fetisisa 2. Batla lipampiri tsa lipatlisiso tse hatisitsoeng ka sehlooho sa hau u sebelisa laeborari ea lithuto tse hatisitsoeng o sebelisa melao ea hau ea ho batla (mohlala, ha e eo pele ho 3). Na re ka sebelisa bopaki (na ke mohloli o tšepahalang)? 2020. U saletsoe ke lithuto tsa hau ho bala ka botlalo, ho ntša lintlha le ho bapisa liphetho

Ba ile ba fumana eng?

Lipampiri tse hlahlobiloeng li bonts'itse hore kalafo ea TKI ho osteosarcoma e ka ba tsela e sebetsang litseleng tsa kalafo tse tlang. Meriana e supileng ea TKI e ile ea khetholloa e le phekolo e ka khonehang ka ho lebisa tlhokomelo ea TKR ho osteosarcoma. Bafuputsi le bona ba hlokometse tse latelang:

• Ho lumellana ho lebisitsoeng ho motho ka mong oa phekolo ea TKI ho mokuli e mong le e mong ho ka ntlafatsa liphello bakeng sa bakuli ba osteosarcoma. • Sena se ka etsoa ka ho sebelisa li-biomarker ho bakuli tse ka bapisoang le meriana ea TKI bakeng sa mokhoa o hlophisitsoeng. Leha ho le joalo, phekolo ea TKI feela ha ea lekana ho phekola osteosarcoma. • Ho kopanya phekolo ea TKI le chemotherapy ho ile ha tsejoa e le moralo o sebetsang haholoanyane oa phekolo. • Ho hlokahala liteko tse kholo tsa kliniki ho utloisisa hore na li-TKI le chemotherapy li sebetsa hantle hakae e le leano le ka khonehang la kalafo bakeng sa linyeoe tseo osteosarcoma e hasaneng ho feta 'meleng (metastatic).
Biomarker definition: letshwao la baeloji la tshebetso ya mmele le ka thusang ho hlahloba bokuli (mohlala ho lekanya maemo a aene disampole tsa madi ho hlahloba phokolo ya madi)

Litla-morao tsa kalafo e ne e le lebaka le tloaelehileng la ho fetola meriana kalafong. Litla-morao li ka ama boleng ba bophelo ba bakuli. Bangoli ba khothaletsa hore litekong tse kholoanyane tsa kliniki bakeng sa ts'ebeliso ea motsoako oa TKI / chemotherapy ho osteosarcoma, boleng ba bophelo bo shejoe le mokuli e mong le e mong ho utloisisa sena hamolemo.

See se bolelang?

Bangoli ba khethile mokhoa oa kalafo bakeng sa osteosarcoma e nang le kalafo e lebisitsoeng ea TKI hammoho le chemotherapy. Nakong e tlang, liteko tse kholo tsa kliniki li khothaletsoa ho theha kalafo ena. Litekong tsena tsa kliniki ho ka ba bohlokoa ho sheba boleng ba bophelo ba bakuli ho bona hore na motsoako ona oa phekolo o ntlafatsa boleng ba bophelo hammoho le ho thusa bakuli ho tsoela pele ka TKI le phekolo ea chemotherapy bakeng sa kankere.

Tlhaloso:
Assi A, Farhat M, Hachem MCR, Zalaquett Z, Aoun M, Daher M, Sebaaly A, Kourie HR. Tyrosine kinase inhibitors ho osteosarcoma: ho fetola mekhoa ea phekolo. J Bone Oncol. 2023 Nov 3;43:100511. doi: 10.1016/j.jbo.2023.100511. PMID: 38058514; PMCID: PMC10696463.