The British Sarcoma Group (BSG) musangano wepagore zvakaitika munaKurume 22nd - 23rd 2023 muNewport, Wales. Takafara kupinda semuratidziri wekusimudzira zvedu Osteosarcoma Zvino Kuedza Kuongorora (ONTEX) uye vedu 2023 kupa mari kutenderera. Zvaikurudzirawo kunzwa zvichangobva kuitika mukurapwa kwemasarcoma. Kune akawanda akasiyana marudzi e sarcomas. Osteosarcoma (OS) imhando yebhonzo sarcoma.
Genomics uye Sarcoma
Kunzwisisa shanduko mune yedu genetic code inotungamira mukuumbwa kwegomarara kwakakosha. Inogona kubatsira kutungamira tsvakiridzo mukugadzirwa kwemishonga mitsva pamwe nekuti munhu angaite sei pakurapwa kwakapihwa. Nzira inonzi whole genome sequencing (WGS) inoongorora genetic code yedu uye inogona kutsvaga shanduko. WGS ikozvino yave kuwanikwa kune vanhu vane sarcoma muEngland. Nekudaro, hapana vanhu vakakwana vari kuwana izvi uye hapana data rakakwana riri kugadzirwa. Sarcoma UK vanga vachitarisa muzvipingamupinyi zvekuti vanhu vasvike paWGS uye vaona nzvimbo dzakakosha dzinogona kuvandudzwa kuwedzera huwandu hwe data. Vakaona kuti pakanga paine kusaziva kweWGS mune zvehutano pamwe nekushaikwa kunofungidzirwa kubatsira kwekutumira varwere kuWGS. Izvo zvakare zvakashumwa kuti hapana yakamisikidzwa chibvumirano chirongwa. Kuwana mvumo kubva kuvanhu kuti ubatanidzwe inguva inopedza uye inoda kuitwa nemazvo kuitira kuti data richengetedzwe uye rishandiswe nenzira kwayo mune ramangwana. Zvakakoshawo kufunga kuti WGS ingashandiswa sei kubatanidza vanhu nemiedzo yekiriniki. Kune akawanda makiriniki ekuedza ari kuyedza mishonga mitsva inonangana neiyo genetic mutation. WGS ichaona vanhu vane genetic mutations uye inogona kuve mukana wekuvasanganisa mumakiriniki ekuedzwa.
The West Midlands Sarcoma TumorHuwandu hwemasero ari kukura paasingafanirwe kunge ari. Mabundu anogona kuva akaipa kana kuti akaipa. Benign tumors haapararire kune dzimwe nhengo dzemuviri nepo mamota akaipa ari gomarara uye anogona kupararira. Advisory Board yakagovera mienzaniso chaiyo yehupenyu hwekushandisa kweWGS. Iri boka raive nedata re genomics revanhu makumi matatu nevatatu vane sarcoma, avo vashanu vaive OS. Kubva pane genetics data,
- 5 vanhu vakakurudzirwa kuti vatore chikamu mukuyedzwa kwekiriniki.
- 4 vanhu vakawanikwa vaine genetic mutation uye vakaendeswazve kunoona mazvikokota.
- Iyo genetic data haina kuita mutsauko pakurapwa kwevanhu gumi nevatatu.
- 11 vanhu vaive nemukana wekutora chikamu mukuyedzwa kwekiriniki mune ramangwana.
Izvi zvinosimbisa simba iro WGS inogona kuve nayo mukutungamira kurapwa kwesarcoma.
Kuvhiya kweSarcoma
Chimwe chikamu chemusangano chakatsaurirwa kune zvitsva mukuvhiya kwe sarcoma. Kuvhiya kunowanzoitwa sechikamu chenguva dzose kurapwa kwe sarcoma. Hurukuro dzaive dzakanangana nemhando dzakasiyana kana mativi ekuvhiya. Zvakakosha, matekiniki ari kugadzirwa kuti avandudze mhedzisiro nehupenyu hwevanhu, kunyanya avo vangangoda kudimburwa nhengo. Imwe hurukuro yakasimbisa nyaya yemunhu ane chondrosarcoma (a type of bone sarcoma) mumbabvu. Vakashandisa 3D kudhinda kugadzira prosthesis yekutsiva mbabvu dzaifanira kubviswa pakuvhiyiwa. Imwe hurukuro yakakurukura nezvechirwere chesarcoma pachidya chaida kuti gumbo ridimburwe kubva pabhonzo remuhudyu. Izvi zvine chekuita nemhedzisiro yakaipa pane kudimburwa pamusoro pebvi. Zvisinei, pfupa uye matishu pasi pemabvi zvakanga zvichine utano uye chaizvoizvo zvakakwanisa kusungirirwa pahudyu kuti zvigadzire chigutsa icho prosthesis yaigona kubatanidzwa. Izvi zvakaguma nemugumisiro uri nani kumunhu wacho.
KuporaKurapa kana kutarisirwa kwakagadzirirwa kubatsira kubata zviratidzo zvechirwere asi kwete kuchirapa. Care
Isu takanzwawo kubva kune mamwe masangano anotsigira varwere nezvekurarama nesarcoma isingarapike. Hurukuro kubva kuSarcoma UK uye BCRT vakagovana nyaya dzemurwere uye dzemhuri nezve kurapwa kwepalliative. Zvaiva pachena kuti kazhinji pane kushaikwa kwekutaurirana nevanhu pamusoro pezvinoreva izvi uye chii chiri kuitika. Kune vamwe vanhu, kushandiswa kwezwi rekuti palliative kunogona kuve nechirevo chisina kunaka uye vanofunga kuti rufu rwave pedyo kana izvi kazhinji zvisiri izvo. Humbowo hunoratidza kuti zvikwata zvekuchengeta varwere vanofanirwa kuunzwa nekukurumidza sezvinobvira, asi kuti panofanirwa kuve nekutaurirana kwakajeka kune wese munhu nezve izvi. Baroness Ilora Finley akataurawo nezvezvaakasangana nazvo mukuchengetedza runyararo uye kutarisana nekuguma kwehupenyu. Akataura kuti kupera kwehupenyu hwekutarisira kunofanirwa kusimbisa hupenyu, kuve-kwemunhu uye kuwanikwa 24/7. Munhu wacho anofanira kuteererwa uye kubvunzwa kuti chii chakamukoshera kuitira kuti zvaanoda zvizadziswe.
Kana iwe uchida kutaura nemumwe munhu nezve palliative care, tinokurudzira iyo Sarcoma UK runhare rwekubatsira. Nhamba yavo ndeyemahara kufona mukati meUK uye vanopa hushamwari, nyanzvi uye yakavanzika zano kune wese akabatwa nesarcoma.
Sarcoma Clinical Miedzo
Zvekunyanya kufarira kwatiri, dzaive hurukuro dzezvekuedzwa kwekiriniki. Takanzwa maupdates ku ICONIC muyedzo uye nezve muyedzo mutsva wakadanwa SarcoSIGHT.
ICONIC ine chinangwa chekuunganidza ruzivo rwakadzama kubva kuvarwere veOS mumazera ese kuti vanzwisise zviri nani kuti sei uye nei OS ichiitika. Muyedzo uyu wave kuvhurwa munzvimbo makumi maviri nemana muUK uye watora varwere mazana maviri nemakumi maviri nevana kusvika parizvino. Imwe yedata iri kushandiswa kutarisa rudzi rwekutarisirwa kwekiriniki iyo munhu anogamuchira. Kunyanya, ivo vari kutarisa rudzi rwe scan munhu anogamuchira. Muedzo uyu wakawanawo imwe mari yekuunganidza varwere vakawanda uye kuwedzera basa ravari kuita. Takambobvunzurudza Dr Sandra Strauss avo vari kutungamira kutongwa kweICONIC. Tarisa hurukuro.
SarcoSIGHT muedzo mutsva uri kutarisa kuongorora kushanda kwedhayi refluorescent kubatsira kuvhiyiwa. Dhayi, inonzi indocyanine green (ICG) inotorwa nemasero egomarara. Kamera yakakosha inogona kushandiswa kuona bundu iro rinogona kubatsira vanachiremba vanovhiya kuona kuti vari kubvisa zvese bundu tishu uye vachisiya matishu ane hutano hwakawanda sezvinobvira. Izvi zvinofanirwa kuderedza mukana wegomarara kudzoka. Tarisa kubvunzurudzwa naVaKenneth Rankin, vanotungamira kutongwa. Muyedzo uyu hausati wavhurwa kuti ushandiswe. Nyora kune yedu Newsletter kuti unzwe zvigadziriso nezvezviedzo zvekiriniki uye netsvagiridzo yazvino.
Pamwe chete, zvaikurudzira kunzwa zvichangobva kuitika mu sarcoma uye kuona kufambira mberi kuri kuitwa kune kukanganisa chaiko kune vanhu vakabatwa nesarcoma. Tinotarisira kuona izvi zvichienderera mberi uye kubatsira kuunza nharaunda pamwe chete kuburikidza nekubatana uye kutsvaga mari.