Vatsvagiri vepaYunivhesiti yeEast Anglia vakagadzira mushonga mutsva unoshanda kurwisa cancer yemapfupa kusanganisira osteosarcoma (OS). Mushonga uyu, unonzi CADD522, waratidza mhedzisiro inovimbisa murabhoritari. Iko zvino ichaitwa formal toxicology ongororo isati yapinda muyedzo yekiriniki.
Kuvandudzwa kweCADD522
Kuti ugadzire mushonga unofanirwa kutanga waziva waunoda. Vatsvagiri vepurojekiti iyi vaifarira kuti isiri-coding RNAs inogona kubatanidzwa sei mugomarara remapfupa. MaRNA asina kukodha arimo mumasero mapenyu ese uye anogona kudzora majini. Vakatarisa vasiri-coding RNAs muvanhu vane chondrosarcoma (CS), rudzi rwekenza yemapfupa. Madiki akati wandei asina kukodha maRNA akaonekwa seanobvira madhiraivha egomarara. Izvi zvakatariswa zvakare mune ye3D cancer modhi. Iwo mazinga eimwe diki isina-coding RNA inonzi miR-140 akaonekwa achiwedzera panguva yekukura kwegomarara. Iyi isiri-coding RNA yaizivikanwa kudzora gene rainzi RUNX2. Vatsvakurudzi vakaona kuti kuwedzera kweRUNX2 kwakabatsira kufambira mberi kweCS. Mune mamwe mazwi, RUNX2 yakabatanidzwa mukupararira kwegomarara. Mushure mekuona RUNX2 seyaigona kutariswa mushonga, mushonga (CADD522) wakagadzirwa waizovharisa basa rawo.
Kuedza CADD522 murabhoritari
Zvino sezvo mushonga wakanga wagadzirwa, danho raitevera raive rekuona mhedzisiro yekuvharisa RUNX2 yaive pamasero egomarara. CADD522 yakaedzwa mumhando nhatu dzekenza yemapfupa: CS, Ewing sarcoma (ES) uye OS. Mushonga wacho wakabudirira kuderedza kupatsanurwa kwesero muCS uye OS masero. Mushonga wacho waiva nebimodal effect pamasero eES. Izvi zvinoreva kuti zvakakonzera kuwedzera kwemaseru egomarara pamadosi akaderera, asi zvakadzivirira kupatsanurwa kwesero pamitengo yakakwira.
Iyi mhedzisiro yekutanga yaive ichivimbisa. Zvisinei, pane zvakawanda chete zvinogona kuwanikwa kubva kutarisa masero mundiro. Naizvozvo, timu yekutsvagisa yakaenderera mberi kutarisa CADD522 muOS uye ES mbeva modhi (yakafanana CS modhi haisati yagadzirwa). CADD522 yakaderedza saizi yemamota uye yakawedzera kupona kwese mumhando dzemhuka.
Pamusoro pezvo, mapundu nemabhonzo akatenderedza akaongororwa pachishandiswa a mini CT scan. Kazhinji kenza yemapfupa inokonzera kuchinja muhutano hwemapfupa. Nekudaro, CADD522 yaitaridza kudzikisa shanduko idzi muOS mhuka modhi. Yakanga isinawo migumisiro inokuvadza inooneka.
Chii chinotevera CADD522
Mhedzisiro yekutanga iyi inoratidza kuti CADD522 inogona kuvandudza kupona mugomarara remapfupa. Nekudaro, izvi zvakangoedzwa murabhoritari marongero. Kuti mushonga uyu upinde kliniki miedzo inofanirwa kuenderera mberi nekuferefetwa kunosanganisira toxicology ongororo kuti ione kana yakachengeteka. Izvi zvinowanzotora makore mashoma. Tariro ndeyokuti mune ramangwana mushonga uyu unogona kupa mushonga mutsva wevarwere vekenza yemapfupa uye kuva nemigumisiro shoma pane chemotherapy.
Mhoro,
Ini ndiri mudzidzi wechikoro chesekondari ari kunyora bepa pamusoro pekurapa kutsva kwegomarara kwegomarara remapfupa. Ndine mibvunzo mishoma...
1) Kemikari iyi ichapedzwa sei kana kupihwa murwere, inoiswa muropa (senge IV)?
2) Ndeapi nzira kana madosi akapihwa mbeva mhedzisiro isati yaonekwa?
3)Kemikari iyi tingaiwanepi? inowanika kupi? inogona kugadzirwa here kana kugadzirwa?
Ndatenda,
Julie
Mhoro Julie,
Ndinokutendai nekufarira kwenyu gomarara remapfupa.
1) Basa rakawanda richada kuitwa kuona nzira yekupa mushonga muvanhu. Yakapihwa nejekiseni reIntraperitoneal (jekiseni mugomba remuviri) kune mhando dzemhuka dziri muchidzidzo chino.
2) Muyero weCAD522 waienderana nehuremu hwemodhi yembeva uye wakapihwa jekiseni kweanosvika mavhiki manomwe. Mhando dzakasiyana dzekenza yemapfupa dzakapindura zvakasiyana. Semuenzaniso osteosarcoma yakaratidza kuderedzwa kwesero kudzokorora mushure memaawa makumi manomwe nemaviri.
3) Yakanga yakagadzirwa.
Rumwe ruzivo runogona kuwanikwa mubepa resainzi. Ini ndaizotarisa panhanganyaya nehurukuro: https://www.sciencedirect.com/science/article/pii/S2212137423000076?via%3Dihub